Dr. McGrail, Associate Professor, received her BS in Biochemistry from the University of Massachusetts, Amherst and her PhD in Molecular and Cellular Biology from the University of Minnesota. Her previous positions include postdoctoral work at the University of California-San Diego, Myriad Genetics in Salt Lake City, and the Huntsman Cancer Institute at the University of Utah.
The McGrail lab studies brain development and disease using the zebrafish genetic model system. We develop CRISPR gene editing tools for functional genomics and disease modeling. Our research examines RB and TP53 tumor suppressors in brain development, in order to understand how their loss drives brain tumor cell proliferation and survival. We are also building novel in vivo models of neural inflammation using CRISPR to investigate pathways driving neurodegenerative disease.